mPRMT1 Recombinant Protein
Produktgrößen
50 µg
£528,00
32-2734-50UG
Über dieses Produkt
- SKU:
- 32-2734
- Zusätzliche Namen:
- ANM1||HCP1||HRMT1L2||IR1B4||Interferon receptor 1-bound protein 4||EC 2.1.1||Protein arginine N-methyltransferase 1||Prmt1||AW214366||6720434D09Rik.
- Weitere Details:
- Source : Escherichia Coli. PRMT1 Mouse Recombinant fused with His-MBP tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 750 amino acids and having a molecular mass of 84 kDa.The PRMT1 is purified by proprietary chromatographic techniques. PRMT1 Methylates (mono & asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones). Methylates SUPT5H.The PRMT1 protein functions as a histone methyltransferase specific for H4.PRMT1 is an essential factor in oncogenesis and is a potential novel therapeutic target in cancer.PRMT1-mediated methylation serves as a positive modulator of IR/IRS-1/PI3K pathway and glucose uptake in skeletal muscle cells. CAF1 is a new regulator of PRMT1-dependent arginine methylation.PRMT1 arginine-methylates MRE11 therefore it regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response.PRMT1 plays a post-translationally part in regulating the transcriptional activity.PRMT1is found predominantly in the cytoplasma though a fraction of PRMT1 is located in the nucleus.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg