PDE6H Recombinant Protein
Produktgrößen
10 µg
£528,00
32-2650-10UG
Über dieses Produkt
- SKU:
- 32-2650
- Zusätzliche Namen:
- Phosphodiesterase 6H||CGMP-Specific||Cone||Gamma||Retinal Cone Rhodopsin-Sensitive CGMP 3';5'-Cyclic Phosphodiesterase||Subunit Gamma||EC 3.1.4.35||EC 3.1.4.17||RCD3||GMP-PDE Gamma||ACHM6||PDE6H.
- Weitere Details:
- Source : Escherichia Coli. PDE6H Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 106 amino acids (1-83 a.a) and having a molecular mass of 11.5 kDa. PDE6H is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. PDE6H belongs to the rod/cone cGMP-PDE gamma subunit family; which selectively catalyze the hydrolysis of 3 cyclic phosphate bonds in adenosine and/or guanine 3;5 cyclic monophosphate (cAMP and/or cGMP). This family regulates the cellular levels; localization and duration of action of these second messengers by controlling the rate of their degradation. PDE6H is the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase; which is a tetramer composed of two catalytic chains (alpha and beta); and two inhibitory chains (gamma). PDE6H is particularly expressed in the retina; and is implicated in the transmission and amplification of the visual signal. Mutations in PDE6H have been associated with retinal cone dystrophy type 3A.
- Aufreinigung:
- Greater than 80% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg