PAPP-A Recombinant Protein
Produktgrößen
10 µg
£528,00
32-2642-10UG
Über dieses Produkt
- SKU:
- 32-2642
- Zusätzliche Namen:
- Pappalysin-1||Pregnancy-associated plasma protein A||PAPP-A||Insulin-like growth factor-dependent IGF-binding protein 4 protease||IGF-dependent IGFBP-4 protease||IGFBP-4ase||PAPPA||PAPA||DIPLA1||PAPPA1||ASBABP2.
- Weitere Details:
- Source : Escherichia Coli. PAPP-A Human Recombinant produced in E.Coli is single; a non-glycosylated; Polypeptide chain containing 191 amino acids fragment (81-271) corresponding to the PAPP-A 'Jelly-Roll' domain fragment; having a total molecular mass of 30kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The PAPP-A is purified by proprietary chromatographic techniques. PAPPA is a large zinc binding protein; which acts as a metalloprotease and specifically cleaves IGFBP-4 and IGFBP-5; resulting in release of bound IGF. PAPP-A can also act as a regulator of IGF bioactivity in a number of biological systems; including the human ovary and cardiovascular systems. It was shown that PAPP A levels are elevated in patients with unstable angina or acute myocardial infarction. Furthermore; PAPPA is believed to be involved in local proliferative processes such as wound healing and bone remodeling. Moreover; PAPP-A is produced in high concentrations during pregnancy and is released into the maternal circulation. In placenta; PAPP A is expressed in X cells in septa and anchoring villi; and in syncytiotrophoblasts in the chorionic villi. Lower levels of PAPPA are found in an array of other tissues including kidney; myometrium; endometrium; ovaries; breast; prostate; bone marrow; colon; fibroblasts and osteoblasts. PAPP-A is present in serum and placenta during pregnancy; with levels increasing throughout pregnancy. Low levels of PAPP A are associated with a number of foetal chromosomal abnormalities; as well as pre-eclampsia and stillbirth.PAPPA levels may be a potentially highly specific marker for heart disease.PAPP-A proteolytic activity is inhibited by targeting substrate exosite binding.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Please avoid freeze thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg