OAS1 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-2630-10UG
Über dieses Produkt
- SKU:
- 32-2630
- Zusätzliche Namen:
- 2'-5'-oligoadenylate synthetase 1||(2-5')oligo(A) synthetase 1||2-5A synthetase 1||p46/p42 OAS||E18/E16||OAS1||OIAS||IFI-4||OIASI.
- Weitere Details:
- Source : Escherichia Coli. OAS1 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 384 amino acids (1-364 a.a.) and having a molecular mass of 43.9kDa.The OAS1 is purified by proprietary chromatographic techniques. OAS1 enzyme is a member of the 2';5'-oligoadenylate synthetase family. OAS1 is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2';5'-oligoadenylates(2-5As). These molecules in turn activate latent RNase L resulting in viral RNA degradation and the inhibition of viral replication. OAS1 may have a role in mediating resistance to virus infection; control of cell growth; differentiation; and apoptosis. OAS1 binds double-stranded RNA and polymerizes ATP into PPP (A2'P5'A)N oligomers; which activate the latent RNase L that; once activated; cleaves single-stranded RNAs. OAS1 gene mutations are been linked to host susceptibility to viral infection. OSA1 gene polymorphisms are linked to the outcome of hepatitis C virus infection. Furthermore; OAS1 gene polymorphisms are linked to the susceptibility to severe acute respiratory syndrome.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- OAS1 although stable 4[o]C for 4 weeks; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg