NEIL2 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-2603-10UG
Über dieses Produkt
- SKU:
- 32-2603
- Zusätzliche Namen:
- Endonuclease 8-like 2||DNA glycosylase/AP lyase Neil2||DNA-(apurinic or apyrimidinic site) lyase Neil2||Endonuclease VIII-like 2||Nei homolog 2||NEH2||Nei-like protein 2||NEIL2||NEH2.
- Weitere Details:
- Source : Escherichia Coli. NEIL2 Human Recombinant produced in E.coli is a single; non-glycosylated polypeptide chain containing 356 amino acids (1-332) and having a molecular mass of 39.4kDa.NEIL2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Endonuclease 8-like 2 (NEIL2) is a member of a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases set off the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break through the associated lyase reaction. NEIL2 is involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. NEIL2 has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). NEIL2 has insignificant or undetectable activity with 8-oxoguanine; thymine glycol; 2-hydroxyadenine; hypoxanthine; and xanthine. NEIL2 also has AP (apurinic/apyrimidinic) lyase activity and creates incisions in the DNA strand. NEIL2 cleaves the DNA backbone by beta-delta exclusion to produce a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. NEIL2 is found in the testis; skeletal muscle; heart; brain; placenta; lung; pancreas; kidney and liver.
- Aufreinigung:
- Greater than 85.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg