MMP2 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-2547-10UG
Über dieses Produkt
- SKU:
- 32-2547
- Zusätzliche Namen:
- 72 kDa type IV collagenase||72 kDa gelatinase||Gelatinase A||Matrix metalloproteinase-2||MMP-2||TBE-1||MMP2||CLG4A||CLG4||MONA||MMP-II.
- Weitere Details:
- Source : Escherichia Coli. MMP2 Human Recombinant produced in E.coli is a single; non-glycosylated polypeptide chain containing 576 amino acids (110-660a.a) and having a molecular mass of 64.7kDa. MMP2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Matrix metalloproteinase-2 (MMP-2) is a type IV collagenase; which is involved in endometrial menstrual breakdown; regulation of vascularization and the inflammatory response. MMP-2 contains a number of distinct domains: a prodomain that is cleaved upon activation; a catalytic domain containing the zinc binding site; a fibronectin like domain believed to have a role in substrate targeting; and a carboxyl terminal (hemopexin like) domain containing 2 N-linked glycosylation. The MMP-2 can degrade an extensive array of substrates including type IV; V; VII and X collagens as well as gelatin type I. In addition; MMP-2 interacts with THBS2; TIMP2; Thrombospondin 1; CCL7 and TIMP4. MMP-2 autocatalytic cleavage in the C-terminal generates the anti-angiogenic peptide; PEX. This process seems to be made possible by binding integrinv/beta3. Defects in the MMP-2 are the cause of Torg-Winchester syndrome (TWS); aka multicentric osteolysis nodulosis and arthropathy (MONA).
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Assay Kits:MMP
- Datenblatt des Herstellers:1.jpg