HERC5 Recombinant Protein
Produktgrößen
20 µg
£528,00
32-2437-20UG
Über dieses Produkt
- SKU:
- 32-2437
- Zusätzliche Namen:
- HERC5||HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 5||CEB1||Hect Domain and RLD 5||Cyclin-E-Binding Protein 1||CEBP1||HECT Domain and RCC1-Like Domain-Containing Protein 5||E3 ISG15--Protein Ligase HERC5||Probable E3 Ubiquitin-Protein
- Weitere Details:
- Source : Escherichia Coli. HERC5 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 367 amino acids (681-1024 a.a.) and having a molecular mass of 43kDa. HERC5 is fused to a 23 amino acid His-tag at N-terminus. HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 5 (HERC5) is a member of the HERC family of ubiquitin ligases; found in a cluster of HERC family genes on chromosome 4. HERC5 is a protein with a HECT domain and 5 RCC1 repeats. The HERC5 protein localizes to the cytoplasm and perinuclear region and serves as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. HERC5 exhibits antiviral activity towards HIV-1; influenza A virus and human papillomavirus. HERC5 is a major E3 ligase for ISG15 conjugation. HERC5 also serves as a positive regulator of innate antiviral response in cells induced by interferon. Pro-inflammatory cytokines upregulate HERC5 in endothelial cells. HERC5 is physically connected with polyribosomes; broadly modifies recently synthesized proteins in a cotranslational fashion.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg