GSTO1 Mutant Recombinant Protein
Produktgrößen
10 µg
£528,00
32-2414-10UG
Über dieses Produkt
- SKU:
- 32-2414
- Zusätzliche Namen:
- Glutathione S-transferase omega-1||GSTO 1-1||GSTO1||GSTTLP28||P28||DKFZp686H13163.
- Weitere Details:
- Source : Escherichia Coli. Several polymorphisms in the coding regions of the human GSTO1 have been identified. A polymorphism causing an alanine-to-aspartate (A140D) substitution in amino acid 140 produces a variant with lowered enzyme activities in the arsenic biotransformation.GSTO1 Variant Human Recombinant produced in E.Coli is single; a non-glycosylated; Polypeptide chain containing 241 amino acids fragment (1-241) having a total molecular mass of 36kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The GSTO1 is purified by proprietary chromatographic techniques. GSTO1 belongs to the theta class glutathione S-transferase-like (GSTTL) protein family. GSTO1 is expressed in a broad array of human tissues and exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities as well as catalyzing the reduction of monomethylarsonate which is an intermediate in the pathway of arsenic biotransformation. Furthermore; GSTO1 shields from oxidative stress which is a risk factor for Alzheimer disease; vascular dementia and stroke. GSTO1 is abundant in alveolar macrophages and airway secretions; with the levels reduced in chronic obstructive pulmonary disease patients. In mouse; the GSTO1 protein acts as a small stress response protein; probably involved in cellular redox homeostasis.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Please avoid freeze thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg