FKBP4 Recombinant Protein
Produktgrößen
50 µg
£528,00
32-2328-50UG
Über dieses Produkt
- SKU:
- 32-2328
- Zusätzliche Namen:
- HBI||p52||Hsp56||FKBP52||FKBP59||PPIase||FKBP4||FK506-binding protein 4||Peptidyl-prolyl cis-trans isomerase||HSP-binding immunophilin||FKBP52 protein||52 kDa FK506-binding protein||p59 protein.
- Weitere Details:
- Source : Escherichia Coli. FKBP4 produced in E.Coli is a single;non-glycosylated polypeptide chain containing 479 amino acids (1-459 a.a.) and having a molecular mass of 53.9 kDa.FKBP4 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques. FKBP4 is part of the immunophilin protein family; which takes part in immunoregulation and necessary cellular processes concerning protein folding and trafficking. FKBP4 is a cis-trans prolyl isomerase that connects to the immunosuppressants FK506 and rapamycin. FKBP4 has high structural and functional similarity to FKBP1A; though; FKBP4 does not have immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and is involved in immunoregulatory gene expression in B and T lymphocytes. FKBP4 is known to connect with phytanoyl-CoA alpha-hydroxylase. FKBP4 associates with HSP90 & HSP70 thus takes part in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. FKBP4 highly associates with adeno-associated virus type 2 vectors (AAV) resulting in a considerable increase in AAV-mediated transgene expression in human cell lines. FKBP4 is involved in the optimal use of AAV vectors in human gene therapy.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg