STC 1 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-2082-10UG
Über dieses Produkt
- SKU:
- 32-2082
- Zusätzliche Namen:
- Stanniocalcin-1||STC||STC-1.
- Weitere Details:
- Source : 293 cell line (Human embryonic kidney). Stanniocalcin-1 Human Recombinant produced in 293 cell line is a single; glycosylated; polypeptide chain containing 240 amino acids and having a total molecular mass of 25.9 kDa. The Stanniocalcin contains two extra residues which were used as a spacer and 8 residues form the C-Terminal Flag- tag.Stanniocalcin is purified by proprietary chromatographic techniques.The amino acid sequence of the recombinant human Stanniocalcin-1 is 100% homologous to the amino acid sequence AA 18-247 of the human mature Human Stanniocalcin-1. Stanniocalcin 1 (STC1) is the mammalian homologue of STC; which was originally identified as a calcium/phosphate-regulating hormone in bony fishes. In contrast; STC1 may play an autocrine and paracrine role with pleiotropic effects in mammals. It is expressed in a wide variety of tissues; but unexpectedly is not detected in the circulation under normal circumstances; which is possibly caused by its attaching to soluble and tethered forms of a high-affinity binding protein. STC-1 can affect calcium homeostasis; bone and muscle mass and structure; and angiogenesis through effects on osteoblasts; osteoclasts; myoblasts/myocytes; and endothelial cells in mouse model. Differential regulation of myocardial STC1 protein expression was reported in heart failure. In addition; STC1 may regulate calcium currents in cardiomyocytes and may contribute to the alterations in calcium homeostasis of the failing heart. STC1 was found to be a selective modulator of hepatocyte growth factor (HGF)-induced endothelial migration and morphogenesis; an inhibitor of macrophage chemotaxis and chemokinesis; suppressor of progesterone and luteinization inhibitor. Together with STC-2; it may play important roles in the processes of implantation and decidualization in the rat. In terminally differentiated adipocytes; it may function as a 'survival factor'; which contributes to the maintenance of the integrity of mature adipose tissue. In context with its possible role in gestation; a Big STC; a three highermolecular- mass variant has been described. STC1 was identified as one of hypoxia-responsive genes coupled to hypoxia-driven angiogenesis.Current research indicates that STC-1 might be a useful molecular marker to detect tumor cells in blood and bone marrow from patients with various types of malignancies.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized STC-1 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution Stanniocalcin should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg