GUCA2B Recombinant Protein
Produktgrößen
10 µg
£528,00
32-2040-10UG
Über dieses Produkt
- SKU:
- 32-2040
- Zusätzliche Namen:
- Guanylate cyclase activator 2B||UGN||GCAP-II||GUCA2B.
- Weitere Details:
- Source : Escherichia Coli. Prouroguanylin Human Recombinant is 10 kDa protein containing 88 amino acid residues of the human prouroguanylin and 2 additional amino acid residues.GPVYIQYQGF RVQLESMKKL SDLEAQWAPS PRLQAQSLLP AVCHHPALPQ DLQPVCASQE ASSIFKTLRT IANDDCELCV NVACTGCLThe Prouroguanylin is purified by proprietary chromatographic techniques. Prouroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen.Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leading to elevated blood pressure independent of the level of diatary salt intake.Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids.
- Aufreinigung:
- Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated thaw-freeze cycles and store at -80[o]C. Reconstituted protein can be stored at 4[o]C for a limited period of time.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg