TARC Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1999-20UG
Über dieses Produkt
- SKU:
- 32-1999
- Zusätzliche Namen:
- C-C motif chemokine 17||Small-inducible cytokine A17||Thymus and activation-regulated chemokine||CC chemokine TARC||ABCD-2||CCL17||CCL-17||SCYA17||TARC||A-152E5.3||MGC138271||MGC138273.
- Weitere Details:
- Source : Escherichia Coli. CCL17 Human Recombinant produced in E.Coli is a single;non-glycosylated; polypeptide chain containing 71 amino acids and having a molecular mass of 8 kDa. The TARC is purified by proprietary chromatographic techniques. TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members; CCL-17 has approximately 24-29% amino acid sequence identity with RANTES; MIP-1a; MIP-1b; MCP-1; MCP-2; MCP-3 and I-309. TARC is expressed in thymus; and at a lower level in the lung; colon; and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4; a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes; but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
- Aufreinigung:
- Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized TARC although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution TARC should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg