MIP 3 Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1964-20UG
Über dieses Produkt
- SKU:
- 32-1964
- Zusätzliche Namen:
- C-C motif chemokine 23||Small-inducible cytokine A23||Macrophage inflammatory protein 3||Myeloid progenitor inhibitory factor 1||CK-beta-8||MIP-3||MPIF-1||CKB-8||CCL23||MIP3||MPIF1||SCYA23||CKb8||Ckb-8-1.
- Weitere Details:
- Source : Escherichia Coli. MIP-3 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 99 amino acids and having a molecular mass of 11.3kDa. The MIP-3 is purified by proprietary chromatographic techniques. CCL23 (MIP-3) is a ligand for the CCR1chemokine receptor. CCL23 is one of several cytokine genes clustered on the q-arm of chromosome 17; in a locus containing several other CC chemokines. MIP-3 chemoattracts monocytes; resting T-lymphocytes and neutrophils; but not activated lymphocytes. Furthermore; it was shown that MIP-3 inhibits colony formation of bone marrow myeloid immature progenitors. MIP-3 is mainly expressed in lung and liver tissue; but can be also found in bone marrow and placenta; as well as in some cell lines of myeloid origin. Alternative splicing of the CCL23 gene produces 2 mRNAs which encode a short (CK8) and a long (CK81) isoform of the MIP-3. CK8 cDNA encodes a 120 amino acid residue precursor protein with a putative 21 a.a. residue signal peptide which is cleaved to generate a 99 a.a. residue mature CK8 (a.a. 22-120). Further N-terminal processing of the 99 a.a. residue variant can produce a 75 a.a. residue CK8 (a.a. 46-120) which is considerably more active than the 99 a.a. residue variant.MIP-3 may be involved in the malignant progression of certain human cancer cells which overexpress ErbB2 through the transactivation of ErbB2 tyrosine kinase. MIP-3 may also be involved in angiogenesis via upregulation of matrix metalloproteinase MMP-2 expression.
- Aufreinigung:
- Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized MIP-3 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution CCL23 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg