Skip to content

Warenkorb

Der Warenkorb ist leer.

Gesamt (exkl. MwSt.) £0,00
Warenkorb überprüfen & bezahlen

TNF-Alpha; Soluble (human) (rec.)

Produktgrößen
50 µg
£458,00
32-190056-50UG
Über dieses Produkt
SKU:
32-190056
Zusätzliche Namen:
Tumor Necrosis Factor Ligand Superfamily Member 2; Cachectin
Weitere Details:
Source : E. coli Binds to human and mouse TNF-R1.Tumor necrosis factor (TNF; cachexin or cachectin and formerly known as tumor necrosis factor-Alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-Alpha; whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-Alpha (MultimericTNF-Alpha). Since the MultimericTNF-Alpha mimics the membrane-bound form (forms oligomers higher than trimer); it is the only TNF-Alpha protein that can activate the TNF-R2. For TNF-R1 activation; either normal" TNF-Alpha or MultimericTNF-Alpha can be used."
Aufreinigung:
>=95% (SDS-PAGE)
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Stable for at least 6 months after receipt when stored at -20[o]C. Working aliquots are stable for up to 3 months when stored at -20[o]C.
Hersteller:
Abeomics
Typ:
Proteins, Peptides, Small Molecules & Other Biomolecules
  • Datenblatt des Herstellers:1.jpg
Figure 1: TNF-Alpha; Soluble (human) (rec.) induces NF-kB dependent genes. Methods: Endothelial cells (HUVEC) are incubated for 1h in the presence of BAY 11-7082 and then treated with TNFAlpha (20ng/ml) (red bar) or incubated with TNFAlpha (20ng/ml) (in the presence or absence of TNF-R1 (human):Fc (human) (rec.) (0.5µg/ml) (blue and gray bar; respectively). TNFAlpha-induced genes expression such as E-Selectin or MCP-1 are tested by flow cytometry.