IL-33 (oxidation resistant) (human) (Recombinant) (His)
Produktgrößen
10 µg
£506,00
32-190054-10UG
100 µg
£952,00
32-190054-100UG
Über dieses Produkt
- SKU:
- 32-190054
- Zusätzliche Namen:
- IL-33 (human) (C208S / C227S / C232S / C259S Mutant); Interleukin-33 (human) (C208S / C227S / C232S / C259S Mutant); IL-1F11; NF-HEV
- Weitere Details:
- Source :E. coli Specific Binds to human and mouse ST2.Interleukin-33 (IL-33; HF-NEV; IL-1F11); a member of the IL-1 family of cytokines; is expressed by many cell types following pro-inflammatory stimulation and is tho µght to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88; IRAK; IRAK4 and TRAF6; followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1); p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types; like Th2-like cells; mast cells and B1 cells; and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases; such as arthritis; asthma; atopic allergy & anaphylaxis; cardiovascular disease/atherosclerosis; nervous system diseases and sepsis. IL-33 facilitates Treg expansion in vitro and in vivo. Recently; IL-33 has been involved in adipocyte differentiation. The biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by its oxidation (formation of two disulfide bridges); resulting in an extensive conformational change that disrupts the ST2 binding site. Cysteines at amino acids C208; C227; C232 and C259 control IL-33 oxidation and mutations of two or more of these four cysteines protect IL-33 from oxidation and increase its activity.
- Aufreinigung:
- >=95% (SDS-PAGE)
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Short Term Storage +4[o]C ; Long Term Storage-20[o]C ;After reconstitution; prepare aliquots and store at -20[o]C. Avoid freeze/thaw cycles. PBS containing at least 0. 1% BSA should be used for further dilutions. Stable for at least 6 months after receipt when stored at -20[o]C. Working aliquots are stable for up to 3 months when stored at -20[o]C.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php