mCXCL16 Recombinant Protein
Produktgrößen
25 µg
£528,00
32-1866-25UG
Über dieses Produkt
- SKU:
- 32-1866
- Zusätzliche Namen:
- C-X-C motif chemokine 16||Small-inducible cytokine B16||Transmembrane chemokine CXCL16||Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein||SR-PSOX||Cxcl16||Srpsox||Zmynd15||AV290116||BB024863||0910001K24Rik.
- Weitere Details:
- Source : Escherichia Coli. CXCL16 Mouse Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 88 amino acids and having a molecular mass of 9.9kDa. The CXCL16 is purified by proprietary chromatographic techniques. Mouse CXCL16 is a nonELR motif including CXC chemokine with a transmembrane domain. Mouse CXCL16 cDNA encodes a 246 a.a. precursor protein with a putative 26 a.a. residue signal peptide; an 88 a.a. residue chemokine domain; an 87 a.a. residue mucinlike spacer region; a 22 a.a. residue transmembrane domain; and a 23 a.a. residue cytoplasmic tail. CXCL16 induces a strong chemotactic response and calcium mobilization. Furthermore; CXCL16 acts as a scavenger receptor on macrophages; which specifically binds to OxLDL (oxidized low density lipoprotein); suggesting that it may be involved in pathophysiology such as atherogenesis. Mouse CXCL16 is generated by dendritic cells in lymphoid organ T cell zones as well as by cells in the splenic red pulp both as membranebound and soluble forms. CXCR6/Bonzo (STRL33 and TYMSTR) is the receptor for CXCL16. CXCL16 is expressed in the spleen; lymph nodes; and Peyer patches. It is also expressed in non-lymphoid tissues such as lung; kidney; small intestine; and thymus; with weak expression in heart and liver and no expression in brain and purified B- and T-cells.CXCL16 deficiency is linked to breast cancer progression. In addition; CXCL16 is involved in immunological liver injury by regulating T lymphocyte infiltration in liver tissue. Furtheremore; CXCL16 has a distinctive role in the maintenance of cardiac allograft tolerance mediated by natural killer T cells. Moreover; CXCL16 has a significant role in not only the production of IFN-gamma by NKT cells; but also promotion of Th1-inclined immune responses mediated by NKT cells.
- Aufreinigung:
- Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized CXCL16 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution CXCL16 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg