BCA 1; His Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1854-20UG
Über dieses Produkt
- SKU:
- 32-1854
- Zusätzliche Namen:
- C-X-C motif chemokine 13||Small-inducible cytokine B13||B lymphocyte chemoattractant||CXC chemokine BLC||CXCL13||BCA1||BCA-1||CXCL-13||B cell Attracting Chemokine-1||BLC||ANGIE||BLR1L||SCYB13||ANGIE2.
- Weitere Details:
- Source : Escherichia Coli. BCA 1 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain topological domain containing 110 amino acids (23-109 a.a) and having a molecular mass of 12.7kDa. BCA 1 is fused to a 23 amino acid His-tag at N-terminus. BCA-1 is a CXC chemokine that is highly expressed in thesecondary lymphoid organs; such as follicles of the spleen; lymph nodes; and Peyer's patches. CXCL13 promotes the migration of B lymphocytes (compared to T cells and macrophages); by stimulating calcium influx into; and chemotaxis of; cells expressing Burkitt's lymphoma receptor 1 (BLR1). BCA1 therefore function in the homing of B lymphocytes to follicles. Human BCA-1 shares a 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA1 is a potent chemoattractant for B lymphocytes but not T lymphocytes; monocytes or neutrophils. BLR1; a G protein-coupled receptor originally isolated from Burkitt's lymphoma cells; has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages; the expression of BLR-1; now designated CXCR-5; is restricted to B lymphocytes and a subpopulation of T helper memory cells.
- Aufreinigung:
- Greater than 85.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- CCL3L1 should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg