Visfatin Recombinant Protein
Produktgrößen
25 µg
£528,00
32-1849-25UG
Über dieses Produkt
- SKU:
- 32-1849
- Zusätzliche Namen:
- PBEF||Pre-B cell colony-enhancing factor||Nicotinamide phosphoribosyltransferase NAmPRTase||Nampt||MGC117256||DKFZP666B131||1110035O14Rik.
- Weitere Details:
- Source : Escherichia Coli. Visfatin Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 466 amino acids. The total molecular mass is 52.6kDa (calculated). The Visfatin is purified by Flag-affinity chromatography. Excess adiposity is the most important risk in the development of insulin resistance and type 2 diabetes mellitus (T2DM). Adipose tissue produces several proteins (adipocytokines) such as leptin; adiponectin; resistin; tumor necrosis factor-; and IL-6; that modulate insulin sensitivity and appear to play an important role in the pathogenesis of insulin resistance; diabetes; dyslipidemia; inflammation; and atherosclerosis. However; the mechanisms by which fat tissue induces insulin resistance and the role of adipocytokines in the pathogenesis of T2DM have not been well established. Visfatin; also known as pre-B cell colony-enhancing factor (PBEF); is a cytokine that is highly expressed in visceral fat and was originally isolated as a secreted factor that synergizes with IL-7 and stem cell factors to promote the growth of B cell precursors. Visfatin homologs have been identified in carp; invertebrate mollusks; and bacteria; as well as in vertebrates; including humans and the mouse. It has been postulated to play a role in innate immunity.Visfatin exerts insulin-mimetic effects that are dose-dependent and quantitatively similar to those of insulin in stimulating muscle and adipocyte glucose transport; and in inhibiting hepatocyte glucose production. Intravenous injection of recombinant visfatin in mice decreased plasma glucose in a dose-dependent fashion. In keeping with its insulin-mimetic effects; visfatin was as effective as insulin in reducing hyperglycemia in insulin-deficient diabetic mice. Visfatin was also found to be bound to and activate insulin receptor; causing receptor phosphorylation and the activation of downstream signaling molecules. However; visfatin and insulin did not compete for binding to the insulin receptor; indicating that the two proteins were recognized by different regions of the receptor. Thus; visfatin might play a role in glucose homeostasis and dysregulation in biosynthesis or signal transduction; and might contribute to the pathogenesis of diabetes.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Visfatin although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution Visfatin should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg