TNF a Mutant Recombinant Protein
Produktgrößen
50 µg
£528,00
32-1790-50UG
Über dieses Produkt
- SKU:
- 32-1790
- Zusätzliche Namen:
- TNF-alpha||Tumor necrosis factor ligand superfamily member 2||TNF-a||Cachectin||DIF||TNFA||TNFSF2.
- Weitere Details:
- Source : Escherichia Coli. Tumor Necrosis Factor-a Variant Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 151 amino acids and having a molecular mass of 16598 Dalton. The TNF-alpha Variant is purified by standard chromatographic techniques. The clinical use of the potent anti-tumor activity of TNF-a has been limited by the proinflammatory side effects including fever; dose-limiting hypotension; hepatotoxicity; intravascular thrombosis; and hemorrhage. Designing clinically applicable TNF-a mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-a; which binds to the murine TNF-R55 but not to the mouse TNF-R75; exhibits retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF-a; which binds to both murine TNF receptors. Based on these results; many TNF- mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro; and exhibited lower systemic toxicity in vivo. Recombinant Human TNF-a Variant/Mutant compared with the wild-type; has an amino acid sequence deletion from a.a. 1-7; and the following a.a. substitutes Arg8; Lys9; Arg10 and Phe157 which is proven tohave more activity and with less inflammatory side effect in vivo.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Tumor Necrosis Factor-a Variant although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution TNF-a Variant should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg