4 1BBL; His Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1780-20UG
Über dieses Produkt
- SKU:
- 32-1780
- Zusätzliche Namen:
- CD137L||CD137-L||4-1BBL||4-1BB Ligand||TNFSF9||Tumor Necrosis Factor (ligand) Superfamily Member 9.
- Weitere Details:
- Source : Escherichia Coli. TNFSF9 Human Recombinant fused to 37 amino acids His tag at N-terminus produced in E.Coli is a single; non-glycosylated polypeptide chain containing 222 amino acids (71-254 a.a.) and having a molecular mass of 23.8 kDa. The TNFSF9 37 aa His tag fusion protein is purified by proprietary chromatographic techniques. 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9; which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines; and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells; macrophages; dendritic cells; activated T cells; neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:Protein image-2.jpg