4 1BBL Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1779-20UG
Über dieses Produkt
- SKU:
- 32-1779
- Zusätzliche Namen:
- CD137L||CD137-L||4-1BBL||4-1BB Ligand||TNFSF9||Tumor Necrosis Factor (ligand) Superfamily Member 9.
- Weitere Details:
- Source : Escherichia Coli. 4 1BBL Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 184 amino acids and having a molecular mass of 19.5kDa.The 4 1BBL is purified by proprietary chromatographic techniques. 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9; which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines; and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells; macrophages; dendritic cells; activated T cells; neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized 4 1BBL although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution 4 1BBL should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:Protein image-2.jpg