Recombinant human NKG2D protein with N-terminal mouse Fc
Produktgrößen
50 µg
£688,00
32-17061-50UG
Über dieses Produkt
- SKU:
- 32-17061
- Zusätzliche Namen:
- NKG2D;CD314;KLRK1;NK cell receptor D
- Weitere Details:
- Expression Host : HEK293 The protein has a predicted molecular mass of 42.8 kDa after removal of the signal peptide.The apparent molecular mass of NKG2D-mFc is approximately 50-65 kDa due to glycosylation. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins; which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex; a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins; where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system; and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C; member 4) family member in the same cluster.
- Aufreinigung:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -80[o]C for 12 months (Avoid repeated freezing and thawing)
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg
