Prl R Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1688-20UG
Über dieses Produkt
- SKU:
- 32-1688
- Zusätzliche Namen:
- PRL-R||hPRLrI.
- Weitere Details:
- Source : Escherichia Coli. Extra Cellular Domain Prolactin Receptor Human Recombinant produced in E.Coli is a non-glycosylated; Polypeptide chain containsing 210 amino acids and having a molecular mass of 23.97 kDa. The Prolactin Receptor is purified by proprietary chromatographic techniques according to Bignon et al. (1994) JBC 269; 3318-24 and tested according to Gertler et al. (1996) JBC 271; 24482-91. Prolactin is a pituitary hormone that plays a role in the stimulation of milk production; salt and water regulation; growth; development and reproduction. The primary step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine receptors. Prolactin is a hormone involved in a range of significant functions including ion transport and osmoregulation; stimulation of milk; protein synthesis as well as the regulation of numerous reproductive functions. Prolactin exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane Prolactin receptor. PRLR varies in size (short and long forms) with tissue source and species; from ~40 kDa to 100 kDa. The PRL-R consists of at least 3 separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site; a single transmembrane domain and a cytoplasmic region; the length of which appears to influence ligand binding and regulate cellular function.
- Aufreinigung:
- Greater than 97.0% as determined by:(a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.(c) Gel filtration at pH 8 under non denaturative conditions.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized PRL-R although stable at room temperature for 1-2 weeks; should be stored desiccated below -18[o]C or preferably even at -80[o]C to prevent dimer formation. Upon reconstitution PRL-R should be stored sterile at 4[o]C between 2-7 days and for future use below -18[o]C. For long term storage at 4[o]C it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles as they cause oligomerization of the protein.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg