NRG1 B1 Recombinant Protein
Produktgrößen
50 µg
£528,00
32-1621-50UG
Über dieses Produkt
- SKU:
- 32-1621
- Zusätzliche Namen:
- Neuregulin-1||Heregulin-b1||NRG1-B1||NRG1 B1.
- Weitere Details:
- Source : Escherichia Coli. Recombinant Human Neuregulin-1/Heregulin-b1 produced in E.Coli is a single; non-glycosylated; polypeptide chain (a.a 177-241) containing 65 amino acids and having a total molecular mass of 7.5kDa. NRG1-B1 is purified by proprietary chromatographic techniques. Neuregulin/Heregulin is a family of structurally related polypeptide growth factors which are stemmed from alternatively spliced genes (NRG1; NRG2; NRG3 and NRG4). Thus far; there are more than 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-b1 is comprised of an Ig domain and an EGF-like domain which is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding stimulates erb3 and erb4 heterodimerization with erb2; promoting intrinsic kinase activity; which results in tyrosine phosphorylation. Even though HRG1-b1 biological effects are still unclear; it has been discovered to advance motility and invasiveness of breast cancer cells which in addition might entail up-regulation of expression and function of the autocrine motility-promoting factor (AMF).
- Aufreinigung:
- Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized NRG1-B1 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution NRG1-B1 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg