INSR Recombinant Protein
Produktgrößen
10 µg
£528,00
32-1542-10UG
Über dieses Produkt
- SKU:
- 32-1542
- Zusätzliche Namen:
- Insulin receptor||IR||EC 2.7.10.1||CD220||INSR||HHF5.
- Weitere Details:
- Source : HEK 293. Insulin Receptor Human Recombinant produced in HEK cells is a single; glycosylated; polypeptide chain (aa 28-944 of the short isoform- HIR-A; Uniprot accession # P06213-2 which includes the whole subunit alpha and extracellular domain of subunit beta) containing a total of 927 amino acids; having a molecular mass of 105.9kDa (calculated); though it migrates at approximately 160kDa on SDS PAGE; the INSR is fused to a 2 a.a N-terminal linker; a 2 a.a C-terminal linker and fused to a 6 a.a His tag at C-Terminus.The Human INSR is purified by proprietary chromatographic techniques. Insulin Receptor (INSR) is a receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Once the precursor signal peptide is removed; the insulin receptor precursor is post-translationally cleaved into 2 chains (alpha and beta) which are covalently linked. Insulin binding initiates phosphorylation of several intracellular substrates; including; insulin receptor substrates (IRS1; 2; 3; 4); SHC; GAB1; CBL and other signaling intermediates. Each of these phosphorylated proteins function as docking proteins for other signaling proteins which contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues; including the p85 regulatory subunit of PI3K and SHP2.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg