IL 32A Recombinant Protein
Produktgrößen
10 µg
£528,00
32-1513-10UG
Über dieses Produkt
- SKU:
- 32-1513
- Zusätzliche Namen:
- NK4||TAIF||TAIFa||TAIFb||TAIFc||TAIFd||IL-32beta||IL-32alpha||IL-32delta||IL-32gamma||Interleukin-32||IL-32||Natural killer cells protein 4||Tumor necrosis factor alpha-inducing factor||IL-32a||IL32a||IL32||Interleukin-32 alpha.
- Weitere Details:
- Source : Escherichia Coli. Interleukin-32 human recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 131 amino acids and having a molecular mass of 14.9 kDa. IL-32 is part of the cytokine family and contains a tyrosine sulfation site; 3 potential N-myristoylation sites; multiple putative phosphorylation sites; and an RGD cell-attachment sequence. IL-32 expression is elevated after the activation of T-cells by mitogens or the activation of NK cells by IL-2. IL-32 induces the production of TNF-a from macrophage cells. IL-32 pro-inflammatory pathway is activated in response to influenza A virus infection. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Induction of TNF; IL-1beta; and IL-6 by IL-32 is intervened by p38-MAPK. IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic; caspase-3-dependent mechanisms. IL32 plays an important role in the pathogenesis of rheumatoid arthritis. IL-32 is involved in activation-induced cell death in T cells; through its intracellular actions. IL-32 is a cell-associated proinflammatory cytokine; which is particularly stimulated by mycobacteria through a caspase-1- and IL-18-dependent production of interferon gamma.IL-32 is associated with TNF-a; IL-1beta; and IL-18. IL32 is involved in human rheumatoid arthritis and is a novel target in autoimmune diseases.
- Aufreinigung:
- Greater than 97.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized IL32 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution IL32 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg