IL 24 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-1500-10UG
Über dieses Produkt
- SKU:
- 32-1500
- Zusätzliche Namen:
- C49A||FISP||MDA7||ST16||IL-24||IL10B||Mob-5||MDA-7||Suppression of tumorigenicity 16 protein||Melanoma differentiation-associated gene 7 protein.
- Weitere Details:
- Source : Sacharomyces cerevisiae. Interleukin 24 human recombinant produced in yeast is a single; glycosylated; polypeptide chain containing 158 amino acids and having a molecular mass of 18 kDa. As a result of glycosylation; the protein migrates at 19.5 kDa on SDS-PAGE. IL24 is a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. IL-10B encoded can induce apoptosis selectively in various cancer cells. Overexpression IL-24 leads to elevated expression of several GADD family genes; which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38); and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells; but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. The glycosylation is essential for activity of IL-24. Functionally; IL-24 has diverse activities. At low concentrations; it induces type I proinflammatory cytokines such as IFN-g; IL-1b; IL-12 and TNF-a. At high concentration; it is a strong inducer of apoptosis in tumor cells; but not normal cells. mda-7/IL-24 is being hailed as a 'magic bullet' for cancer gene therapy.
- Aufreinigung:
- Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized MDA7 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution MDA-7 Recombinant should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg