IL 15 His Recombinant Protein
Produktgrößen
10 µg
£528,00
32-1456-10UG
Über dieses Produkt
- SKU:
- 32-1456
- Zusätzliche Namen:
- IL-15||MGC9721.
- Weitere Details:
- Source : Escherichia Coli. Interleukin-15 His Human Recombinant produced in E.Coli is single; a non-glycosylated; Polypeptide chain containing 123 amino acids fragment (49-162) having a total molecular weight of 13.9 kDa with an C-terminal hexahistidine tag. The IL-15 His is purified by proprietary chromatographic techniques. The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits; and may compete for the same receptor; and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases; as well as the phosphorylation and activation of transcription activators STAT3; STAT5; and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L); possibly through the transcription activation activity of STAT6; and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Please avoid freeze thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg