Thromboplastin Bovine
Produktgrößen
50000U
£727,00
32-13805-50000U
150000 U
£1062,00
32-13805-150000U
Über dieses Produkt
- SKU:
- 32-13805
- Zusätzliche Namen:
- Tissue factor; Coagulation factor III; Thromboplastin; CD142; TF; F3; TFA.
- Weitere Details:
- Source:Bovine Lung. Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder. Biological Activitynull Tissue factor is well-known as the main cellular initiator of blood coagulation. The Tissue factor gene encodes coagulation factor III which is a cell surface glycoprotein that enables cells to initiate the blood coagulation cascades; and functions as the high-affinity receptor for the coagulation factor VII. Following vessel injury; the Tissue Factor and Factor VIIa complex activates the coagulation protease cascade; which leads to fibrin deposition and activation of platelets. The ensuing complex presents a catalytic event; which is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Therefore; Tissue factor has a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Tissue Factor can also be stimulated by the inflammatory mediators interleukin 1 and TNF; as well as by endotoxin; to appear on monocytes and vascular endothelial cells as a component of cellular immune response.Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not been described. Certain levels of Tissue Factor are essential for the maintained viability and growth of endothelium and Tissue Factor-expressing tumor cells. Additionally; abnormal Tissue Factor expression inside the vasculature initiates life threatening thrombosis in various diseases; for example sepsis; atherosclerosis; and cancer. Alternative spliced Tissue Factor expression advances tumor growth; and is linked to increased tumor cell proliferation and angiogenesis in pancreatic cancer. Thromboplastin bovine native
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Bovine Thromboplastin although stable at room temperature for 3 weeks; should be stored desiccated below -18C. Upon reconstitution Prothrombin should be stored at 4C between 2-7 days and for future use below -18C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php