GLP1R Human
Produktgrößen
2 µg
£452,00
32-13678-2UG
10 µg
£528,00
32-13678-10UG
Über dieses Produkt
- SKU:
- 32-13678
- Zusätzliche Namen:
- GLP1; GLP2; GRPP
- Weitere Details:
- Source:Escherichia Coli.Physical Appearance:Filtered White lyophilized (freeze-dried) powder.Biological ActivitynullThe glucagon-like peptide-1 receptor; also known as GLP1R; is a receptor protein found on brain neurons and beta cells of the pancreas. GLP1R activates a signalling cascade that leads to the initiation of adenylyl cyclase and increased intracellular cAMP levels. In humans; GLP1R is synthesized by GLP1R gene; which is present on chromosome 6. GLP1R takes part in the control of blood sugar level by enhancing insulin secretion. GLP1R is a part of the glucagon receptor family of G protein-coupled receptors. GLP1R consists of two domains; one transmembrane (TMD) domain; that binds the N-terminal region of GLP-1. And one extracellular (ECD) which binds the C-terminal helix of GLP-1. The TMD domain contains a fulcrum of polar residues that controls the biased signaling of the receptor; while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.GLP1R Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain (aa 24-145) containing 132 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 15.55 kDa (calculated).
- Format:
- GLP1R filtered (0.4 µm) and lyophilized from 0.5mg/ml in 50mM Acetate Buffer; pH 4.0.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Peptides
- Datenblatt des Herstellers:download_pdf.php