IL21R Mouse
Produktgrößen
2 µg
£452,00
32-13658-2UG
10 µg
£528,00
32-13658-10UG
Über dieses Produkt
- SKU:
- 32-13658
- Zusätzliche Namen:
- Interleukin-21 receptor; IL-21 receptor; IL-21R; Il21r; Lymphocyte receptor beta; LR-beta; Novel interleukin receptor; Novel cytokine receptor 8; NR8; Novel interleukin receptor; CD360; CD360 antigen; NILR; Nilr.
- Weitere Details:
- Source:HEK293 Cells.Physical Appearance:Sterile filtered colorless solution.Biological ActivityMeasured by its ability to inhibit IFN-g secretion using NK-92 human natural killer cells. The ED50 range = 4 ug/ml with mouse IL-2.IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells; stimulation (in conjuction) with IL-4 of IgG production; and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally; IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor; IL-21R; which also contains the gamma chain (?c) found in other cytokine receptors including IL-2; IL-4; IL-7; IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3; followed by activation of the transcription factors STAT1 and STAT3.IL21R Mouse Recombinant produced in HEK293 Cells is a single; glycosylated polypeptide chain containing 457amino acids (20-237 a.a) and having a molecular mass of 52 kDa.IL21R is expressed with a 239 amino acid hIgG-His-Tag at C-Terminus and purified by proprietary chromatographic techniques.
- Format:
- The IL21R solution (0.25mg/1ml) contains PBS (pH7.4) and 10% glycerol.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen at -20[o]C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php