IL-17E Human; HEK
Produktgrößen
2 µg
£452,00
32-13655-2UG
10 µg
£528,00
32-13655-10UG
Über dieses Produkt
- SKU:
- 32-13655
- Zusätzliche Namen:
- interleukin-25 isoform 1; interleukin 25; IL17E; IL-17E; IL25; IL-25; interleukin-17E; interleukin-25.
- Weitere Details:
- Source:HEK293.Physical Appearance:Sterile Filtered colorless solution.Biological ActivityMeasured by its binding ability in a functional ELISA with Human IL-17 RB.IL-17Ealso called IL-25;has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation; and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK; p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness; a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation; jaundice; and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn’t induce allergic inflammation in vivo.IL-17E Human Recombinant produced in HEK293 cells is a single; non-glycosylated polypeptide chain containing 154 amino acids (33-177a.a) and having a molecular mass of 17.8kDa.IL-17E is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
- Format:
- IL-17E protein (0.5mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 20% glycerol.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php