RARRES2 Human; Sf9
Produktgrößen
1 µg
£452,00
32-13376-1UG
5 µg
£528,00
32-13376-5UG
Über dieses Produkt
- SKU:
- 32-13376
- Zusätzliche Namen:
- Retinoic Acid Receptor Responder 2; Chemerin; Retinoic Acid Receptor Responder (Tazarotene Induced) 2; Tazarotene-Induced Gene 2 Protein; RAR-Responsive Protein TIG2; TIG2; Retinoic Acid Receptor Responder Protein 2; HP10433; Retinoic acid receptor responder protein 2; Chemerin; RAR-responsive prot
- Weitere Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered colorless solution.RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 is upregulated by the synthetic retinoid tazarotene and found in a vast variety of tissues. RARRES2 acts as an adipokine; and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors; cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity; which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor; ChemR23 (CMKLR1); as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. The Chemerin receptor has another ligand; called tazarotene-induced gene.RARRES2 produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 146 amino acids (21-157a.a.) and having a molecular mass of 16.9kDa. (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). RARRES2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php