IRF 3 Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1335-20UG
Über dieses Produkt
- SKU:
- 32-1335
- Zusätzliche Namen:
- IRF-3||IRF3||Interferon Regulatory Factor 3.
- Weitere Details:
- Source : Escherichia Coli. IRF-3 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 111 amino acids (1-112) and having a molecular mass of 13 kDa.The Interferon Regulatory Factor-3 is purified by proprietary chromatographic techniques. Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response; hemopoiesis; and proliferation. IRF-3 is a member of the IRF family; and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change; leading to its dimerization; nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1); a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn-alpha and ifn-beta promoters respectively. IRF-3 does not have any transcription activation domains.
- Aufreinigung:
- Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Liquid Interferon although stable at 10[o]C for 1 week; should be stored below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg