ICOS Human
Produktgrößen
1 µg
£452,00
32-13266-1UG
5 µg
£528,00
32-13266-5UG
Über dieses Produkt
- SKU:
- 32-13266
- Zusätzliche Namen:
- Inducible T Cell Costimulator; Activation-Inducible Lymphocyte Immunomediatory Molecule; Inducible T-Cell Costimulator; AILIM; Inducible T-Cell Co-Stimulator; Inducible Costimulator; CD278 Antigen; CD278; CVID1.
- Weitere Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered colorless solution.ICOS (inducible T-cell costimulatory) belongs to the CD28 family of immune-assisted stimulatory receptors. ICOS forms homodimers and takes a significant part in immune responses; cell-cell signaling; as well as regulation of cell proliferation. The interaction of B7-H2 / ICOS takes a vital role in T-cell differentiation; T-B cell interaction in addition to humoral immune response is essential for the formation of reproductive centers as well as the production of cytokine IL-4. Moreover; ICOS is more effective in inducing IL-10 production; a cytokine which is important for the inhibitory function of T regulatory cells. The ICOS-B7RP-1 and B7-1 / B7-2-CD28 / CTLA-4 pathways offer a significant second signal which can regulate the inhibition; activation and fine regulation of T-lymphocyte responses. ICOS stimulates the production of Th1 and Th2 cytokines; however it can also participate in the generation of Th2 cells.ICOS produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 362 amino acids (21-140a.a.) and having a molecular mass of 40.8kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). ICOS is expressed with an 242 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php