ICAM1 Human; Sf9
Produktgrößen
2 µg
£452,00
32-13262-2UG
10 µg
£528,00
32-13262-10UG
Über dieses Produkt
- SKU:
- 32-13262
- Zusätzliche Namen:
- Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor; ICAM-1; Intercellular Adhesion Molecule 1 (CD54); Human Rhinovirus Receptor; Cell Surface Glycoprotein P3.58; Human Rhinovirus Receptor; CD54 Antigen; P3.58; CD54; BB2; Intercellular adhesion molecule 1.
- Weitere Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered colorless solution.ICAM-1 also called CD54 is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic and haematopoietic cell types and has roles in signal transduction; cell signaling and lymphocyte adhesion. ICAM1 binds to integrins such as CD11a / CD18; or CD11b / CD18. ICAM1 is also used by Rhinovirus as a receptor. ICAM-1 is an intercellular adhesion molecule constantly present in low concentrations in the membranes of leukocytes and endothelial cells. When stimulated by cytokine the concentrations significantly increase. ICAM-1 can be stimulated by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFA) and is expressed by the vascular endothelium; macrophages and lymphocytes. ICAM-1 is a ligand for LFA-1 which is a receptor found on leukocytes. Upon activation; leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 is implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be notably elevated in patients with SAH. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions.ICAM1 produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 692 amino acids (28-480a.a.) and having a molecular mass of 76.5kDa. (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). ICAM1 is expressed with a 239 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php