CDH5 Human
Produktgrößen
2 µg
£452,00
32-13138-2UG
10 µg
£528,00
32-13138-10UG
Über dieses Produkt
- SKU:
- 32-13138
- Zusätzliche Namen:
- Cadherin 5; VE-Cadherin; Cadherin 5 Type 2 VE-Cadherin (Vascular Epithelium); CDH5; Cadherin 5 Type 2 (Vascular Endothelium); Vascular Endothelial Cadherin; 7B4 Antigen; Endothelial-Specific Cadherin; Cd144 Antigen; CD144 Antigen; Cadherin-5; CD144; 7B4.
- Weitere Details:
- Source: Sf9; Insect cells.Sterile filtered colorless solution.Cadherin-5 (CDH5) belongs to the atypical/type 2 subgroup of Cadherin homophilic adhesion proteins. Cadherin-5 is a calcium-dependent cell-cell adhesion molecule; which is comprised of 5 extracellular cadherin repeats; a transmembrane region and a highly conserved cytoplasmic tail. Cadherin-5 protein plays a role in the formation; maturation and remodeling of the vascular wall. CDH5 is generally considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin; often co-existing with N-cadherin. Moreover; the CDH5 protein regulates or is regulated by VEGF R2; type 1 and type 2 TGF-beta receptors; and other endothelial junction proteins such as JAM-C; Claudin-5; and N-Cadherin. CDH5 also connects with alpha-catenin forming a link to the cytoskeleton. CDH5 functions jointly with KRIT1 to create and maintain correct endothelial cell polarity and vascular lumen. Furthermore; Cadherin-5 is essential for activation of PRKCZ and for the localization of phosphorylated PRKCZ; PARD3; TIAM1 and RAP1B to the cell junction. The CDH5 gene is located in a gene cluster in a region on the long arm of chromosome 16 which is involved in loss of heterozygosity events in breast and prostate cancer.Cadherin 5 Human Recombinant produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 810 amino acids (29-599 a.a.) and having a molecular mass of 91.5kDa (Migrates at 70-100kDa on SDS-PAGE under reducing conditions). CDH5 is expressed with a 239 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php