GM CSF Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1281-20UG
Über dieses Produkt
- SKU:
- 32-1281
- Zusätzliche Namen:
- CSF-2||MGI-1GM||GM-CSF||Pluripoietin-alpha||Molgramostin||Sargramostim||MGC131935||MGC138897.
- Weitere Details:
- Source : Escherichia Coli. Granulocyte Macrophage Colony Stimulating Factor Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 127 amino acids and having a molecular mass of 14477 Dalton. GM-CSF is purified by proprietary chromatographic techniques. Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) was first characterized as a growth factor that supports the in-vitro colony formation of granulocytes-macrophages progenitor cells (1; 2). It is a pleiotropic cytokine and a member of a family of endogenous cytokines of the hematopoietic system. GM-CSF is produced as a response to immune or inflammatory stimuli by activated cells of the hematopoietic system such as T cells; B cells; macrophages; mast cells and also fibroblasts and alveolar epithelial cells. It plays an important role in regulating the proliferation; differentiation; survival and activation of hematopoietic cells such as granulocytes and monocytes ;neutrophiles; basophiles and eosonophoiles; erythroid cells; megakaryocytes and T cells (3;4). Human and mouse GM-CSF have about 56% homology and are species specific. Human GM-CSF is not active on mouse cells and vice versa. It is active on canine and feline cells (5; 6).GMCSF is 144 amino acids; 22kDa glycoprotein. It is composed of four bundles alpha helices. Its receptor is heterodimers with a ligand-specific alpha subunit and a betac (c) subunit that is shared with the interleukin IL-3 and IL-5 receptors. This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors. Cross-linking the two receptor subunits is required for receptor activation and signaling (7; 8).GMCSF has been shown to be involved in maturation; mobilization and antigen presentation of myeloid dentritic cells (DCs) in-vivo or ex-vivo. This function promotes Th1 immune responses; cytotoxcity; anti-angiogenesis as well as allergic inflammation; and the development of autoimmunity (9-11). Therefore GMCSF can be used in immunotherapy for the treatment of immune suppressed and immune-compromised patients as well as in veterinary medicine for the same purpose (12-14). GM-CSF is also important in regulation of embryo development and pregnancy and specifically in embryo implantation and subsequent development (15; 16).
- Aufreinigung:
- Greater than 98.0% as determined by1. Analysis by RP-HPLC.2. Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Granulocyte Macrophage Colony Stimulating Factor although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution GMCSF should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg