LGALS1 Recombinant Protein
Produktgrößen
50 µg
£528,00
32-1218-50UG
Über dieses Produkt
- SKU:
- 32-1218
- Zusätzliche Namen:
- Galectin-1||GAL1||GAL-1||Lectin galactoside-binding soluble 1||Beta-galactoside- binding lectin L-14-I||Lactose-binding lectin 1||S-Lac lectin 1||Galaptin||14 kDa lectin||HPL||HBL||Putative MAPK-activating protein PM12||GBP||DKFZp686E23103.
- Weitere Details:
- Source : Escherichia Coli. LGALS1 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 134 amino acids and having a molecular mass of 14.5 kDa.The LGALS1 is purified by proprietary chromatographic techniques. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 is an autocrine negative growth factor that regulates cell proliferation. Galectin-1 regulates cell apoptosis and cell differentiation. Galectin-1 binds CD45; CD3 and CD4 & inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of lyn kinase. Galectin-1 and its ligands are one of the master regulators of immune responses as T-cell homeostasis and survival; T-cell immune disorders; inflammation and allergies as well as host-pathogen interactions. Galectin-1 expression or overexpression in tumors and/or the tissue surrounding them must be considered as a sign of the malignant tumor progression that is often related to the long-range dissemination of tumoral cells (metastasis); to their dissemination into the surrounding normal tissue; and to tumor immune-escape. Galectin-1 in its oxidized form plays a number of important roles in the regeneration of the central nervous system after injury. The targeted overexpression (or delivery) of Galectin-1 should be considered as a method of choice for the treatment of some kinds of inflammation-related diseases; neurodegenerative pathologies and muscular dystrophies. In contrast; the targeted inhibition of Galectin-1 expression is what should be developed for therapeutic applications against cancer progression. Galectin-1 is thus a promising molecular target for the development of new and original therapeutic tools. There is 88% homology between the human and mouse galectin-1.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Galectin-1 Recombinant although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution Galectin-1 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg