FGF 19 Recombinant Protein
Produktgrößen
25 µg
£528,00
32-1191-25UG
Über dieses Produkt
- SKU:
- 32-1191
- Zusätzliche Namen:
- Fibroblast growth factor 19||FGF-19||FGF19.
- Weitere Details:
- Source : Escherichia Coli. FGF19 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 195 amino acids and having a molecular mass of 21.8 kDa.The FGF-19 is purified by proprietary chromatographic techniques. The FGFs are a family of more than 20 small (~17-26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1; 2; or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response.FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1; -2; -3; and -4; all with intrinsic tyrosine kinase activity and; except for FGFR-4; multiple splice isoforms; and FGFR-5; which lacks an intracellular kinase domain. There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. The overexpression of a dominant negative form of FGFR-1 in cells leads to diabetes in mice; which thus implies that proper FGF signaling is required for normal cell function and glycemia maintenance. FGFR-2 appears to be a key molecule during pancreatic development. Moreover; FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis.FGF-19; has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin; glucose; and lipid profiles in diabetic rodents. Since these effects; at least in part; are mediated through the observed changes in metabolic rates; FGF-19 can be considered as a regulator of energy expenditure.FGF-21 is preferentially expressed in liver; but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes; protects animals from diet-induced obesity when overexpressed in transgenic mice; and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized FGF-19 Human Recombinant although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution Fibroblast Growth Factor-19 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg