FAS Recombinant Protein
Produktgrößen
20 µg
£528,00
32-1155-20UG
Über dieses Produkt
- SKU:
- 32-1155
- Zusätzliche Namen:
- Tumor necrosis factor receptor superfamily member 6||Apo-1 antigen||Apoptosis-mediating surface antigen FAS||FASLG receptor||CD95||FAS||APT1||FAS1||APO-1||FASTM||ALPS1A||TNFRSF6.
- Weitere Details:
- Source : Escherichia Coli. sFas Receptor Human Recombinant produced in E.coli is a single; non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 17.6kDa.The FAS is purified by proprietary chromatographic techniques. Fas and Fas Ligand (FasL) are members of the TNF superfamily and are type I and type II transmembrane proteins; respectively. Binding of FasL to Fas initiates apoptosis in Fas-bearing cells. The apoptosis mechanism involves the recruitment of pro-caspase 8 through an adaptor molecule named FADD followed by processing of the pro-enzyme to active forms. These active caspases subsequently cleave a variety of cellular substrates leading to the eventual cell death. sFasR is able to inhibit FasL-induced apoptosis by acting as a decoy receptor whicht serves as a sink for FasL. The full length Fas Receptor is a 319 a.a type I transmembrane protein; which contains a 157 a.a extracellular domain; a 17 a.a transmembrane domain; and 145 a.a cytoplasmic domain. The mature human Fas ECD shares 55%; 58%; a.a sequence identity with the mouse; rat; Fas; respectively.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized FAS although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution FAS should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg