Endoglin Sf9 Recombinant Protein
Produktgrößen
10 µg
£528,00
32-1144-10UG
Über dieses Produkt
- SKU:
- 32-1144
- Zusätzliche Namen:
- CD105||ENG||END||ORW||HHT1||ORW1||FLJ41744||Endoglin.
- Weitere Details:
- Source : Sf9 Insect Cells. CD105 Human Recombinant extracellular domain produced in baculovirus is a homodimeric; glycosylated; Polypeptide containing 586 amino acids and having a molecular mass of 61 kDa but as a result of glycosylation; migrates at 90 kDa under reducing conditions in SDS-PAGE. The CD105 is fused to a C-terminal His-tag (6xHis) and purified by proprietary chromatographic techniques. Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells; activated macrophages; fibroblasts; and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1; TGF-beta3; activin-A; BMP-2; and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized Endoglin although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution CD105 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg