proBDNF Recombinant Protein
Produktgrößen
10 µg
£528,00
32-1073-10UG
Über dieses Produkt
- SKU:
- 32-1073
- Zusätzliche Namen:
- proBDNF||Precursor Form Brain-derived Neurotrophic Factor.
- Weitere Details:
- Source : Escherichia Coli. proBDNF Human Recombinant produced in E.Coli is a single; non-glycosylated; non-covalently linked homodimer with each polypeptide chain containing 229 amino acids and having a molecular mass of 52kDa. The proBDNF is purified by proprietary chromatographic techniques. proBDNF (the precursor form of Brain-derived neurotrophic factor) interacts preferentially with p75NTR (the pan-neurotrophin receptor p75) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis; while the mature BDNF selectively binds with great affinity to the TrkB kinase receptor and promotes the survival; growth and differentiation of neurons. Since proneurotrophins and mature neurotrophins bring forth opposite biological effects; proBDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. proBDNF has an important role in negative regulation of neurotrophic actions in the brain.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized proBDNF although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution proBDNF should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:1.jpg