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Antikörper

Anti-Human CD276 Monoclonal Antibody (Clone: 7-517)

Produktgrößen
0.1 mg
£532,00
30-2938-0.1MG
Über dieses Produkt
SKU:
30-2938
Zusätzliche Namen:
B7H3; B7RP-2
translate.label.attr.clone:
7-517
Klonalität:
Monoclonal
Weitere Details:
Specificity: The mouse monoclonal antibody 7-517 recognizes an extracellular epitope of human CD276 (B7H3) transmembrane glycoprotein. Background: CD276 (B7H3) is a type I transmembrane glycoprotein expressed on dendritic cells; osteoblasts; sinonasal epithelium; and upon activation (by inflammatory cytokines) in monocytes; NK cells; T cells and B cells. Although it has been described also as a costimulatory ligand; its major role seems to be inhibitory. It regullates T cell proliferation and functions; and may provide certain tumors with protection against NK cells. CD276 can be used as a marker of neuroblastoma cells in the bone marrow; which is the primary site of neuroblastoma relapse. CD276 (B7H3) is a type I transmembrane glycoprotein expressed on dendritic cells; osteoblasts; sinonasal epithelium; and upon activation (by inflammatory cytokines) in monocytes; NK cells; T cells and B cells. Although it has been described also as a costimulatory ligand; its major role seems to be inhibitory. It regullates T cell proliferation and functions; and may provide certain tumors with protection against NK cells. CD276 can be used as a marker of neuroblastoma cells in the bone marrow; which is the primary site of neuroblastoma relapse.
Format:
Purified
Host:
Mouse
Immunogen:
monocyte-derived dendritic cells
Isotyp:
Mouse IgG1 kappa
Aufreinigung:
Purified by protein-A affinity chromatography.
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2: Flow cytometry multicolor surface staining pattern of human stimulated (GM-CSF + IL-4) monocytes stained using anti-human CD11c (BU15) PE antibody (10 μl reagent / 100 μl of peripheral whole blood) and anti-human CD276 (7-517) purified antibody (concentration in sample 0.19μg/ml) GAM APC.
Figure 3: Separation of human CD11c positive cells stained using anti-human CD276 (7-517) purified antibody (concentration in sample 0.19μg/ml; GAM APC; red-filled) from CD11c positive cells stained using mouse IgG1 isotype control (MOPC-21) purified antibody (concentration in sample 0.19μg/ml; same as CD276 purified concentration; GAM APC; black-dashed) in flow cytometry analysis (surface staining) of human stimulated (GM-CSF + IL-4) monocytes.
Figure 3: Separation of human CD11c positive cells stained using anti-human CD276 (7-517) purified antibody (concentration in sample 0.19μg/ml; GAM APC; red-filled) from CD11c positive cells stained using mouse IgG1 isotype control (MOPC-21) purified antibody (concentration in sample 0.19μg/ml; same as CD276 purified concentration; GAM APC; black-dashed) in flow cytometry analysis (surface staining) of human stimulated (GM-CSF + IL-4) monocytes.