Anti-Human Fc epsilon RIa Monoclonal Antibody (Clone: AER-37 [CRA1])
Produktgrößen
0.1 mg
£532,00
30-2937-0.1MG
Über dieses Produkt
- SKU:
- 30-2937
- Zusätzliche Namen:
- FcµR1; FCER1A
- translate.label.attr.clone:
- AER-37 [CRA1]
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: The mouse monoclonal antibody AER-37 [CRA1] recognizes an extracellular epitope of the high-affinity IgE receptor I alpha subunit (Fc epsilon RIa). Background: FcµRI serves as the IgE Fc-binding subunit of the high-affinity IgE receptor; expressed on the surface of mast cells and basophils. It associates with one beta and two gamma subunits that contain ITAM sequences in their intracellular domains; that function as docking sites in the process of signalosome forming after FcµRI triggering. Attached IgE gives to the receptor specificity for particular antigens which are target of the type I allergen sensitivity or hypersensitivity reaction; and prolongs stability of the receptor on the cell surface. Under physiological conditions this system protects the body against helminths and other parasites and venom toxins; but when dysregulated; it can lead to undesired allergic reactions and anaphylactic shock.
- Format:
- Purified
- Host:
- Mouse
- Isotyp:
- Mouse IgG2b kappa
- Aufreinigung:
- Purified by protein-A affinity chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
