Anti-Hu CD89 APC Mab (A59)
Produktgrößen
100 Tests
£620,00
30-2908-100TESTS
Über dieses Produkt
- SKU:
- 30-2908
- Zusätzliche Namen:
- FcalphaRI; FcAR; CTB-61M7.2
- translate.label.attr.clone:
- A59
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- Specificity: The mouse monoclonal antibody A59 recognizes an extracellular epitope of CD89; a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes; monocytes and macrophages. CD89 (Fc-alpha-R) is a type I transmembrane glycoprotein serving as a receptor for IgA. Soluble CD89 is detectable in serum and retains its IgA binding capacity. For signal transduction the association with FcR gamma chain homodimers is needed. CD89 is expressed on granulocytes; monocytes; macrophages; dendritic cells and myeloid cell lines. Its expression is upregulated in presence of IgA immune complexes; stimulators (such as LPS; PMA); TNF alpha; IL1 beta or GM-CSF; and it is downregulated in presence of TGF beta and suramin. Binding of IgA-opsonized targets to CD89 leads to phagocytic and cytotoxic processes of the immunologic defense.
- Host:
- Mouse
- Immunogen:
- Ag8.653 myeloma cells
- Isotyp:
- Mouse IgG1 kappa
- Aufreinigung:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
