Anti-Hu CD141 Mab (M80)
Produktgrößen
0.1 mg
£541,00
30-2905-0.1MG
Über dieses Produkt
- SKU:
- 30-2905
- Zusätzliche Namen:
- Thrombomodulin; fetomodulin; THBD; THRM; THPH12; TM
- translate.label.attr.clone:
- M80
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: The mouse monoclonal antibody M80 recognizes an extracellular epitope of CD141; a 75 kDa transmembrane glycoprotein expressed mainly on macrophages; monocytes; platelets and endothelial cells. CD141; also known as thrombomodulin or fetomodulin; is a single chain type I transmembrane glycoprotein serving as a receptor for thrombin and as an important cofactor in the protein C anticoagulant system; but it is also involved in embryonic and atherosclerotic plaque development. CD141 is expressed mainly on macrophages; monocytes; a subpopulation of myeloid dendritic cells; on platelets and endothelial cells; but also e.g. on keratinocytes (epithelium). After binding to thrombin; CD141 activates protein C; which degrades clotting factors Va and VIIIa; and as a consequence the amount of thrombin is reduced. Mutations in the CD141 gene can cause a thromboembolic disease known as inherited thrombophilia.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- MV4-11 cell line
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified by protein-A affinity chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
