Anti-CD325 APC Mab(8C11)
Produktgrößen
100 Tests
£620,00
30-2891-100TESTS
Über dieses Produkt
- SKU:
- 30-2891
- translate.label.attr.clone:
- 8C11
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- Specificity: The mouse monoclonal antibody 8C11 recognizes an extracellular epitope of CD325 (N-cadherin); a transmembrane protein associated with actin cytoskeleton system; which is expressed mainly by neurons; osteoblasts; endothelial cells; and stem cells. CD325 (N-cadherin) is a type I transmembrane protein; which forms a complex with catenins; that is linked to the actin cytoskeleton. This complex is important in synapses and for functional plasticity of neurons; and is also essential for embryonic development. Decreased CD325 cleavage caused by mutations in presenilin 1 is associated with Alzheimer´s disease. Besides nervous system; CD325 is expressed on the surface of malignant T cells; and increases their adhesion to epithelia; as well as their ability to invade and metastasize to inflammatory sites.
- Host:
- Mouse
- Immunogen:
- bacterially expressed extracellular domain of human CD325
- Isotyp:
- Mouse IgG1 kappa
- Aufreinigung:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg