Anti-Hu CD21 APC Mab (Clone : LT21)
Produktgrößen
100 tests (T)
£620,00
30-2886-100TESTS
Über dieses Produkt
- SKU:
- 30-2886
- Zusätzliche Namen:
- CR2; C3DR2; CVID7; SLEB9; complement C3d receptor 2
- translate.label.attr.clone:
- LT21
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- Specificity: The antibody LT21 reacts with an extracellular epitope of CD21 (CR2); a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes; follicular dendritic cells; some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells. CD21 (complement receptor 2; CR2) binds C3 complement fragments; especially its breakdown fragments; which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes; survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
- Immunogen:
- IM9 human B-lymphoblastoid cell line
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reaktivitäten:
- Bovine, Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
