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Antikörper

Anti-Human CD74 PE MAb (Clone: LN2)

Produktgrößen
100 tests
£620,00
30-2853-100TESTS
Über dieses Produkt
SKU:
30-2853
Zusätzliche Namen:
p33; DHLAG; HLADG; Ia-gamma
translate.label.attr.clone:
LN2
Klonalität:
Monoclonal
Konjugat:
PE
Weitere Details:
Specificity: The antibody LN2 recognizes an extracellular epitope of CD74 (the MHC II-associated invariant chain; Ii); a type II transmembrane protein expressed in antigen-presenting cells; as well as e.g. on activated neoplastic cells in T cell lymphomas; in lymph node germinal center; mantle zone B cells; histiocytes; interdigitating reticulum cells; Langerhans cells; thymic dendritic cells and peripheral blood B lymphocytes. CD74 (the MHC II-associated invariant chain; Ii) is a type II transmembrane protein expressed in antigen-presenting cells; that serves as MHC II chaperone which promotes MHC II trafficking from the ER to endocytic compartments; prevents peptide binding in the ER and contributes to peptide editing in the MHC II compartment; it is also an accessory signaling molecule implicated e.g. in malignant B cell proliferation. Stimulation of cell surface CD74 leads to NFkappaB activation; which enables entry of the stimulated cell into the S phase. CD74 binds pro-inflammatory cytokine MIF with high affinity and interacts with CD44. Binding of Vpu; an HIV1 protein; to CD74 modulates MHC II presentation.
Host:
Mouse
Immunogen:
SU-DHL-4 lymphoma cells
Isotyp:
Mouse IgG1
Aufreinigung:
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2: Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CD19 (4G7) APC antibody (10 μl reagent / 100 μl of peripheral whole blood) and anti-human CD74 (LN2) PE antibody (20 μl reagent / 100 μl of peripheral whole blood).
Figure 3: Separation of human CD74 positive B cells (red-filled) from CD74 negative CD19 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD74 (LN2) PE antibody (20 μl reagent / 100 μl of peripheral whole blood).
Figure 3: Separation of human CD74 positive B cells (red-filled) from CD74 negative CD19 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD74 (LN2) PE antibody (20 μl reagent / 100 μl of peripheral whole blood).